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Lab Res.
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Histologic Examination of Wounds Treated with BCT Products in an Animal Model Authors: Mark Trumbore, PhD BCT (Balsam Peru, Castor Oil, Trypsin) wound treatments are prescription products containing active ingredients that have been used clinically in combination for over forty years. In spite of this, there has been little effort made to examine the effects of BCT treatments on healing tissue. An animal study was carried out in rats in which wounds were treated with BCT Gel, BCT ointment, BCT spray or saline. After fifteen days of treatment, the rats were euthanized and biopsies were taken from the wound sites. The biopsies were evaluated histologically to determine the effects of the various treatments. All wounds appeared to be fully healed by day fifteen of the study. Comparison of BCT Gel to BCT ointment treated wounds indicated that BCT Gel treated wounds had lower levels of hyperkeratosis, ulceration and inflammation than did wounds treated with BCT ointment. In addition, BCT Gel demonstrated lower incidence of crusting. Comparing BCT Gel to BCT Spray or saline demonstrated that BCT Gel treated wounds demonstrated lower levels of fibrosis, ulceration and inflammation. These results indicate that treatment with BCT Gel showed no adverse histologic results at the wound site. |
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