| 291 |
Clinical Research
|
A clinical study of the ability of BCT Gel to increase epidermal perfusion in peripheral tissue First Author: Mark Trumbore Authors: Mark Trumbore, PhD Successful management of open wounds requires an effective occlusive barrier, adequate blood flow to the wound and effective debridement of necrotic tissue. All of these therapeutic benefits can be delivered by BCT (balsam peru, castor oil, trypsin) products. Previous work has shown that BCT Gel provides an effective occlusive barrier and delivers enhanced enzymatic activity1,2. To date, no studies have examined the ability of BCT Gel to increase tissue perfusion. BCT ointment has been shown to increase capillary blood flow3. However, no definitive correlation exists between either the velocity or quantity of capillary blood flow and wound healing. In contrast, SPP (Skin Perfusion Pressure) has been shown to correlate to wound healing outcomes with SPP values of = 30 mm Hg having a positive correlation with wound healing4,5. The degree of tissue perfusion as determined by measurement of SPP will be done by laser Doppler flowimetry using a SensiLase PAD3000 system (Vasamed, Eden Prarie MN). A ten (10) person clinical trial has been initiated to examine the ability of BCT Gel treatment to increase tissue perfusion in healthy volunteers. These results will be compared to results obtained by treatment with BCT ointment or a barrier ointment. |
|