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Lab Research
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The Ability of a Novel Aerosol Foam Papain-Urea Product to Accommodate Wound Exudate First Author: Mark Trumbore Authors: Mark Trumbore, PhD Surgical debridement has traditionally been used in the management of burns and venous and diabetic ulcers. Recently, enzymatic debridement has gained increased acceptance as an alternative technique1. Papain-Urea products are a popular class of enzymatic debriders all of which contain the two active ingredients, Papain and Urea, at similar concentrations. In order for the treatments to be effective, the formulations must adhere to and cover the entire wound and resist wash-out by wound exudate. Previous work has shown that a Papain-Urea aerosol foam had superior adherence to wet tissue as compared to commercially available Papain-Urea ointments and sprays2. However, these studies failed to consider the results of continued wound seepage on tissue adherence. In this study, the adherence of a Papain-Urea foam product to a simulated wound environment is examined both in the presence and absence of continued seepage and compared to the adherence of both a Papain-Urea ointment and spray. To date, no studies have compared the clinical efficacy of the various Papain-Urea formulations. The results of this study suggest that the tested products differ in their ability to resist wash-out from a wound a finding which may be an important parameter in influencing clinical outcome. |
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