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Lab Research
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Antimicrobial Effect of a Novel Silver Containing Soft Silicone Foam Dressing Against a Broad Range of Wound Pathogens First Author: Farideh Taherinejad Authors: Kristina Hamberg, PhD, Kristina Blom, PhD, Ulrika Genheden MSc, and Malin Prydz, MSc Chronic wounds are often colonised by bacteria, resulting in delayed wound healing[1-3]. Effective antimicrobial dressings are therefore needed for wound treatment. The present study aims to demonstrate the antimicrobial effect of a novel silver containing soft silicone foam dressing* that has been developed based on a patented soft silicone adhesive technology**, comprising a soft silicon contact layer** shown to be atraumatic during use and upon removal[4-7]. The antimicrobial effect was tested against common wound pathogens using the Kirby-Bauer standard method "zone of inhibition"[8], slightly modified, i.e. corrected zone of inhibition (CZOI). Briefly, small pieces of the dressings are placed on agar plates, pre-incubated with bacteria or yeast. After 24 hours further incubation, clear zones around the dressings due to inhibited growth are measured. A soft silicone foam dressing*** without silver was used as control. CZOI of Staphylococcus aureus and Pseudomonas aeruginosa and the yeast Candida albicans were 7.0 (± 0.6) mm, 5.3 (± 1.0) mm and 12.3 (± 2.3) mm, respectively (n=4, +/- stdev). No clear zone was detected around the negative control. This study demonstrates the antimicrobial effect of the silver containing soft silicone foam dressing on Gram positive and Gram negative bacteria as well as yeasts. * Mepilex Ag?, Mölnlycke Health Care AB ** Safetac?, Mölnlycke Health Care AB *** Mepilex?, Mölnlycke Health Care AB |
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