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Lab Research Res.
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High antimicrobial activity and reduced cellular toxicity of a new silver-containing ointment dressing* First Author: Petra Zoellner, PhD Authors: Holger Kapp, MS Hans Smola, MD We investigated the antimicrobial activity of a novel silver-containing ointment dressing*. Moreover, we compared cytotoxic effects of the dressing as well as two other widely used silver-containing dressings on the human keratinocyte cell line HaCaT. A variety of bacteria strains including methicillin-resistant S. areus, S. epidermidis and P. aeruginosa were tested in antimicrobial activity tests. Cytotoxicity of the different silver-containing dressings was analysed on the human keratinocyte cell line HaCaT following the ISO 10993 procedure. The new silver containing ointment dressing effectively killed methicillin-resistant S. aureus and all other gram-positive and gram-negative bacteria tested. The antimicrobial efficacy lasted for at least 9 days with repeated inoculation of the test strains. Most importantly, the silver containing ointment dressing had the lowest cytotoxic effect on HaCaT cells with a viability of more than 90%, followed by the two other silver dressings with only 80% and 2% HaCaT surviving. The new silver-containing ointment dressing has a superior profile of antimicrobial activity over cellular toxicity. This may very well augment tissue repair mechanisms in wounds with delayed healing. *Atrauman Ag, HARTMANN-CONCO Inc. |
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