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Lab Research
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The effect of two ointments containing trypsin, balsam of Peru, and castor oil on the healing of rodent wounds First Author: Raju Vegesna, Ph.D Authors: Raju Vegesna, PhD Introduction: Products containing balsam of Peru, trypsin and castor oil are known to have positive effects on skin health and wound healing (1,2) The balsam of Peru increases local circulation by dilating the cutaneous blood vessels, while trypsin provides proteolytic cleansing of the wound bed (3). Objective: To study the wound healing potential of two ointments containing balsam of Peru, trypsin and castor oil in pre-clinical animal studies of wound healing. Method: Full thickness dermal wounds were produced on the dorsum of Swiss albino mice. Either of Product A* or Product B**, or saline control was applied (20 mice in each group). Progression of wound healing was monitored periodically by capturing video images of the wound at various days post-wounding. Mean wound healing times, were. Results: Treatment with the two test products resulted in significant increase in wound closure rates when compared to the saline control. The results indicate that the two products were equally effective. Conclusion: Use of ointments containing the active ingredients of balsam of peru, trypsin, and castor oil assists in faster wound closure. * Product A: Allanderm ª, Allan Pharmaceuticals, LLC, Huntingdon Valley, PA. ** Product B: Xenaderm ª , Healthpoint Limited, Ft. Worth, TX. |
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