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Clinical Research
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The treatment of full thickness lower extremity wounds with an acellular regenerative tissue matrix: a 1 year study First Author: Stephen Brigido Authors: Edward Schwartz DPM, Raymond McCarroll DPM, Lori Barnett DPM This paper describes the long-term outcome of patients treated with a single application of Graftjacket¨ Regenerative Tissue Matrix (Wright Medical Technology, Arlington, TN) within 8 weeks of first presenting with a diabetic foot ulcer. This study was designed to not only address wound closure but also the durability of wound closure. The goal of this long-term follow-up was to determine whether grafting of the acellular regenerative tissue matrix resulted in functional tissue regeneration -- measured by long-term closure and durability in a series of 20 patients. Of the 20 wounds treated, 17 (85 %) achieved complete healing by 16 weeks. The average time for complete healing was 10.8 + 2.7 weeks. No patients re-ulcerated within the 1 year time frame. The positive long term clinical outcome of a regenerative tissue matrix demonstrates that the scaffolds unique biochemistry may allow for a decrease in the rate of reulceration in full thickness lower extremity wounds. |
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