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Clinical Research
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Using a novel contact layer for the management of epidermolysis bullosa skin lesions First Author: Claudine BLANCHET-BARDON Authors: Claudine Blanchet-Bardon; S. Bohbot Epidermolysis bullosa (EB) is a heterogeneous group of rare, inherited skin diseases characterized by recurrent painful skin lesions, often induced by minor trauma resulting in dermal-epidermal separation or split. A clinical study was undertaken to evaluate the acceptability, tolerance and efficacy of a novel contact layer dressing* in the management of EB skin lesions. Methods: This open-label clinical trial involved 20 patients suffering from EB simplex or dystrophic EB. Patients were selected from the register of EB patients at the investigating center. Skin lesions were treated with the study dressing for a maximum of four weeks. All dressing changes, wound parameters, pain and effect on quality of life were recorded. Results: All the patients completed the trial. Nineteen out of 20 wounds healed within 8.7 +/- 8.5 days. Overall, 11 patients (55%) considered that their quality of life was improved after using the tested dressing, reported to 'very easy' or 'easy' to remove at most dressing changes. Nineteen out of 20 patients stated that they would use this dressing to manage their lesions in the future. Conclusion: This study confirmed the very good acceptability and efficacy of a new contact layer dressing * in the treatment of EB skin lesions. * Restore Contact Layer with Triact Technology, Hollister Wound Care, Libertyville, IL. Supported in part by Hollister Wound Care, LLC |
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