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Laboratory Research
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Efficacy of a wound matrix*, PDGF gel**, and standard of care*** on healing of infected porcine full-thickness wounds N. Barai, K. Lam, J. Cowart, K. Posadas, P. Attar, B. Shroot In individuals with systemic diseases such as diabetes and venous insufficiency, the process of wound healing is slowed. Timely closure of these wounds may reduce the risk of serious and costly complications such as amputation. Standard care often fails to expedite closure of these wounds, and thus, alternative treatment strategies are needed. Oasis is a bioactive extracellular matrix for wound healing that contains critical components of the extracellular matrix such as collagen, proteoglycans, and glycosaminoglycans, as well as active growth factors (eg, transforming growth factor-beta and fibroblast growth factor-2). The objective of this study was to compare the wound healing process of full thickness porcine wounds following treatment with Oasis and other wound care products such as Regranex (a gel containing platelet-derived growth factor-PDGF), DuoDerm (a hydrocolloid dressing) and a moist control. Twenty full thickness wounds were created on the dorsum of the pig with a 2 cm trephine. Following hemostasis, wounds were isolated and bacteria were applied. Each pig was treated with the different treatments (1 pig per treatment) and followed for 21 days. Histopathological measurements, rate of wound closure and bioburden were the different parameters evaluated. Regranex was able to accelerate total wound closure faster than the other treatment groups through day 4. However, by day 7 Oasis-treated wounds appeared to surpass the other treatment groups and by day 11 over 80% of the Oasis-treated wounds were completely reepithelialized. In comparison none of the other treatment groups showed complete reepithelialization. At day 4, the biopsies from the Oasis treated wounds exhibited a deeper granulation bed than did the day 4 biopsies from wounds receiving the other three treatments and by day 14 the wounds treated with Oasis and moist controls were completely covered by epithelium. All of the treatment groups demonstrate some downward trend in bioburden through day 14. Overall, Oasis led to more complete granulation and reepithelialization than the other treatment modalities in this preclinical model *Oasis Wound Matrix¨ , Healthpoint, Fort Worth, TX.**Regranex Gel¨, Johnson & Johnson Wound Management, a division of Ethicon, Somerville, NJ.***Duoderm¨, ConvaTec, Skillman, NJ |
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